Endocrine Abstracts

Objective: One of the ways to predict nephrolithiasis, which is one of the surgical indications in patients with asymptomatic primary hyperparathyroidism, is to detect hypercalciuria. A calcium excretion of >400 mg/day in 24-hour urine, >4 mg/kg/day calcium excretion in 24-hour urine or a fractionated calcium excretion (FECa) >0.010 guide us in the detection of hypercalciuria and therefore nephrolithiasis. The aim of our study is which of these three tests is more ...

Nonclassical Congenital Adrenal Hyperplasia (NCAH) usually due to 21 Hydroxylase deficiency (21OHD) is an autosomal recessive disease, occurring in upto 1/200 of Caucasians and more often in certain ethnic groups. Common CYP21A2 mutations from most severe to mildest are; null, I2 splice, I172N, P30L, and V281L. Mutations leaving 20–70% of enzyme activity is responsible for NCAH, mostly caused by V281L mutation. About 25–50% of patients are homozygous or compound hete...

Introduction: Sodium/glucose co-transporter 2 (SGLT2) inhibitors are a relatively new group of antihyperglycaemic medications for type 2 diabetes mellitus (T2DM). Euglycemic diabetic ketoacidosis (EDKA) and Fournier’s gangrene (FG) are uncommon advers effects of SGLT2 inhibitors. We report a case of a 52-year-old man who developed FG and EDKA after starting the SGLT2 inhibitor empagliflozin.Case Presentation: A-52 years old male patient attended to ...

Introduction: Sodium/glucose co-transporter 2 (SGLT2) inhibitors are novel oral hypoglycemic agents that are increasingly used in the management of type 2 diabetes mellitus (T2DM). They are now recommended as second-line pharmacotherapy (in conjunction with metformin) in patients with type 2 diabetes and established atherosclerotic heart disease, heart failure or chronic kidney disease due to their favourable effects on cardiovascular and renal outcomes. We report a case of a ...

Introduction: Adrenal incidentelomas are new era of the endocrinology. We aimed to see the results of adrenal masses retrospectively.Methods: Patients admitted to the Internal Medicine outpatient clinic for different complaints were retrospectively evaluated. Patients whom abdominal imaging like ultrasonography, magnetic resonance imaging or computed tomography were done and incedentally established adrenal masses were evaluated. Patients with a history ...

Case: A 28-year old man was admitted to our hospital with complaints of three days of severe headache, diplopia and ptosis of the right eye. He had pituitary macroadenoma and had been on cabergolin 0.25 mg/week for the last six months. At physical examination, he demonstrated ptosis and inability to move the right eye medially. Magnetic resonance imaging showed a 13×12 mm pituitary mass with suprasellar extension and hemorrhage. Visual field analysis was abnormal except t...

Introduction: Radiotherapy to the head and neck area is the standard therapy used for the treatment of nasopharyngeal carcinoma. Hypopituitarism is a well-known late complication of cranial radiotherapy. Although very rarely, it may be observed following radiotherapy to the head and neck area, as well.Case report: A 53-year-old man was referred to our endocrinology department for hyponatremia and low free thyroxine (T4) with normal thyroid- st...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy that affects 5–10% of women of reproductive age. It is now recognized as not only a reproductive but also a metabolic disorder with co-morbidities, such as; diabetes, dyslipidemia, hypertension, etc. All these metabolic abnormalities predispose women with PCOS to atherosclerosis. Plasma viscosity is a major determinant of blood flow in microcirculation. Preliminary data indicate that elevated plasma...

There are limited data inquiring the relationship between somatostatin analogues and insulin sensitivity among acromegalic cases. This study was conducted to evaluate short-term effects of lanreotide autogel (LA), administered every 28 days by deep subcutaneous injection, on insulin sensitivity among acromegalic patients with pituitary tumors. Before and following six months of LA treatment, insulin resistance and beta-cell function were calculated by using homeostasis model a...

Background: In the literature there are rare cases of patients with known Type 2 Diabetes Mellitus whom are diagnosed as insulinoma. However a synchronous diagnosis with insulinoma and diabetes for a patient presenting with hypoglycemia symptoms is not an expected condition.Case: A 79 years-old female patient was sent to our Endocrinology outpatient clinic because of repeating minor and major hypoglycemia attacks. She had no important finding in her back...